Key questions in the Buschbeck Lab
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate on the molecular level? How does the environment influence these processes? How does nuclear metabolism impact chromatin structure and the cell’s epigenetic memory?
These are the questions we address in the lab. We combine basic research and applied research. In our basic research, we like to dissect molecular mechanisms of chromatin regulation and evaluate if this knowledge has an application in cancer. We have a long-standing interest in histone variants with macrodomains. In our more applied projects, we screen for novel drug targets for blood cancers and to understand their molecular mode of action.
Background
Marcus Buschbeck, PhD, is a Senior Group Leader at the Josep Carreras Leukaemia Research Institute (IJC), Spain.
He was trained in molecular cancer research and chromatin biology at several institutions that include the Max-Planck-Institute of Biochemistry (Germany), the University of Oxford (UK) and the Center of Genomic Regulation (Spain).
Since 2009, he has been combining these two fields in his own group. He enjoys collaborating with scientists from different disciplines and to find new ways to explore the unknown.