Research synopsis of the Eda Yildirim Lab
Dr. Eda Yildirim uses mammalian X-chromosome inactivation as a model to determine how long noncoding RNA-mediated processes regulate gene expression, impact chromatin state, and participate in cell fate decisions during hematopoiesis and how alterations in these processes impact hematologic malignancies.
Her second interest is in understanding how spatial organization of the genome and gene expression is achieved through interactions that are formed between chromatin and the components of the nuclear pore complex, called nucleoporins.
The aim of her research is to define how chromatin associated function of nucleoporins influence epigenetic gene regulation and genome function during development and cancer. The Yildirim Lab approaches these questions by utilizing a variety of genetic, cell biological, imaging and genomics tools using mouse embryonic and adult stem cells, human cells, and mouse models.