Background
Prof. Lumír Krejčí is Head of the Laboratory of Recombination and DNA Repair (LORD) at Department of Biology at the Masaryk University, Brno (MUNI) of Czech Republic. His research is focused on regulatory processes involved in maintaining genome integrity.
DNA double-strand breaks (DSB) are among the most lethal forms of DNA damage. DSBs are induced by a large number of endogenous and exogenous agents, as genotoxic chemicals and ionizing radiation, or due to replication of damaged DNA as well as collapse of a replication fork. DSB can either be properly repaired, restoring genomic integrity, or miss-repaired resulting in cell death, genomic instability, and cancer. Prof. Lumír Krejčís group focuses on mechanisms of DSB repair using multi-disciplinary approaches.